The two, from Sullivan County, are 14-year-old Yante Teller and her 12-year old brother Chaim Teller. They were last seen by family on Saturday, Dec. 8 at their home in the town of Fallsburg.
The two were last seen getting into a vehicle in front of their home before it drove away, state police said.
The children are not believed to be in any imminent danger and are believed to have traveled to New York City, according to police.
Anyone with information is asked to call 845-292-6600.
Share this story on Facebook by clicking on the Facebook icon below.
Check back to Daily Voice for updates.
Click here to follow Daily Voice Middletown-Wallkill and receive free news updates.